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The US Food and Drug Administration (FDA) has warned against using tadalafil, the active ingredient in the medication Cialis, for erectile dysfunction (ED) in men over the age of 18.

FDA warned that using tadalafil for ED in adult men aged 18 and over could cause “serious and potentially life-threatening side effects”, including:

  • Severe dizziness
  • Headache
  • Nausea
  • Dizziness
  • Confusion
  • Seizures

The agency also warned that using tadalafil for ED in adults could lead to:

  • Severe heart rhythm abnormalities (arrhythmia)
  • Severe dizziness and fainting
  • Low blood pressure

FDA also warned that the drug should not be taken with nitrates for heart problems, and also advised men not to take alpha-blocker drugs, such as Propranolol, because these drugs can cause a serious heart attack or stroke, and may also increase the risk of heart disease.

Tadalafil can interact with several other medicines, including blood thinners and some blood pressure medicines.

However, the agency also advised men not to use tadalafil if they:

  • Are taking any other types of medicines including heart medications
  • Have recently taken a blood thinner
  • Are taking the medication for blood clots, including a heart attack or stroke
  • Are allergic to tadalafil or any ingredients of the medication

The agency also warned that the use of tadalafil for ED in men aged 18 to 41 years old may increase the risk of:

  • Cardiovascular and cerebrovascular events
  • Increased risk of heart attack or stroke
  • Increased risk of heart problems

Tadalafil is not approved for use in children under 18 years of age.

The drug’s manufacturers did not provide any information about the safety or efficacy of tadalafil.

Tadalafil is also not approved for use in women. However, the agency said that a recent study that examined the safety of tadalafil in women showed that there was a slight increase in heart attack and stroke in women in the group who took it, compared to the group who did not.

The drug’s makers did not respond to requests for comment.

Tadalafil may cause some side effects in some people. It is not recommended for use in patients with certain medical conditions, such as severe heart problems, uncontrolled high blood pressure or diabetes. However, it is not recommended for use in men with heart problems. The agency also said that the drug may increase the risk of certain types of cancer, including breast cancer, as well as certain types of prostate cancer. The agency also noted that tadalafil is not approved for use in women.

The agency also warned that tadalafil should not be used if you have heart problems, and if you have a history of heart attacks, angina (chest pain) and heart failure, or if you are taking certain medicines. Tadalafil may be prescribed in some cases for other conditions, such as those listed below.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis's effects on sexual health and sexual function at Tadalafil review.

As with any medication, Cialis can cause a side effectčif at a lower risk if you following aάaese's dietary guidelines.

As with all prescription medications, inform your doctor of any and all medications, prescription drugs, and supplements you are taking.
  • Cialis can also interact with nitrates used for chest pain. If you are taking nitrates for chest pain, it can increase the risk of a sudden and severe decrease in blood pressure.
  • Cialis can cause a milder side effectčif at the lower side than any other prescription medication. However, Cialis can interact with nitrates used for chest pain. If you are using Cialis before sex, your doctor should consider reducing your dose.
  • If you have previously experienced severe side effects (such as prolonged erection or erectile dysfunction), you should seek medical attention immediately. These side effects are typically temporary and not a cause of concern.
  • As with all prescription medications, let your doctor know if you haveucklandwide. This is due to new District of Otago North's classification as a "Smoking Cessation Region."

    In addition, let your doctor know if you are taking any other forms of medication. These include prescription drugs, nonprescription medications, or herbal supplements.

    In the US, start your first dose at the lowest dose that works. Then, if you find that the dose is too high, consult your doctor for additional options.

    May require a dosage adjustment to accommodate your lifestyle.

    It is not known if Cialis is safe or effective during pregnancy. However, consult your doctor if you are pregnant or planning to become pregnant.

    Cialis can cause a side effectčif at the lower side than any other prescription medication.

    As with all prescription medications, let your doctor know if you are taking any form of medication, and it is safe to take Cialis when you are breastfeeding.

    Interactions

    A. Top Drug-Drug Interactions:

    1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

    2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

    3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

    Other Drug-Drug interactions:

    • Ketoconazole, itraconazole (used to manage fungal infection)
    • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
    • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
    • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
    • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

    B. Drug-Food Interactions:

    Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

    1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
    2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
    3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
    4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
    EUhoezeleia-Dosierung:

    Avanafil, Cialis, and Sildenafil:

    cessive intake of fat can exacerbate side effects with PDE5 inhibitors, leading tocribed side effects include:

    1. Nausea and vomiting
    2. Vomiting or lightheadedness
    3. Dizziness
    4. Lightheadedness or fainting

    Here are the key Avanafil, Cialis, and Sildenafil drug-food interactions to be aware of:

    1. High-Fat Mounal meal: While Cialis can be taken with Avanafil, the onset of the medication's effects can vary. Some individuals experience moderate effects on blood pressure or orthostatic hypotension when taking the high-fat meal.
    2. : While Avanafil can be taken with Mounal, the effectiveness of the drug can still be affected.

    Cialis 20mg Tadalafil contains the active ingredient Tadalafil. It is a phosphodiesterase type 5 (PDE5) inhibitor. Cialis 20mg is a generic medication that offers greater flexibility in its usage, allowing individuals to experience a natural and improved flow of blood to the penis without the need for a prescription. This medication is primarily used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). The benefits of taking Cialis 20mg are numerous, which include:

    • Increased sexual arousal
    • Improved erectile function
    • Increased satisfaction with sexual performance

    Why Choose Cialis 20mg?

    Cialis 20mg offers a higher concentration of tadalafil than most other ED and BPH medications. With the increased sexual arousal and improved performance, individuals can experience a natural and improved flow of blood to the penis without the need for a prescription. Cialis 20mg's increased sexual arousal and enhanced sexual performance can enhance the enjoyment of a normal sex life. Furthermore, Cialis 20mg provides greater flexibility in its use, allowing individuals to achieve and sustain an erection without the need for surgery.

    Cialis 20mg works best when taken about an hour before sexual activity. Cialis 20mg may decrease your blood pressure, which may be associated with other heart-related side effects. Therefore, taking Cialis 20mg with meals is generally recommended before anticipated sexual activity.

    Cialis 20mg Benefits

    Cialis 20mg is effective in treating erectile dysfunction (ED) and helping men achieve and maintain erections. It is particularly beneficial for those who experience BPH symptoms, which include difficulty achieving or maintaining an erection, such as difficulty having an erection during sexual intercourse. Cialis 20mg can have a synergistic effect with other ED medications like Viagra, Levitra, or Staxyn, providing more flexibility and sexual arousal. It is important to remember that Cialis 20mg is not intended for use by women and children.

    Cialis 20mg Side Effects

    While Cialis 20mg is generally well-tolerated, like all medications, it can cause side effects. The most common side effects are headache, stuffy nose, indigestion, back pain, muscle aches, and flushing. More serious side effects, such as sudden vision or hearing loss, may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    Cialis 20mg is not intended for use by women or children. Children should only be treated with the medication as it may be damaging to a developing baby. Cialis 20mg should not be used by women or children who are breastfeeding. Cialis 20mg has also been associated with an increased risk of suicidal thoughts and behaviors, especially in males.

    Cialis 20mg Drug Interactions

    Cialis 20mg may interact with other medications, including:

    • Nitrates
    • Alpha-blockers
    • Diuretics
    • Other erectile dysfunction medications

    Women and children should only be treated with the medication as it may be damaging to a developing baby. Cialis 20mg should not be used by women and children who are breastfeeding. Cialis 20mg has also been associated with an increased risk of suicidal thoughts and behaviors, especially males.

    Cialis 20mg Storage

    Store Cialis 20mg at room temperature, away from moisture and heat. Keep it out of reach of children. Cialis 20mg should not be used for prolonged or any conditions.

    Cialis 20mg Precautions

    Cialis 20mg should be used only under the supervision of a healthcare professional. Inform your doctor about any existing medical conditions and allergies you may have. Cialis 20mg may also interact with other medications, including:

    • Other medications for BPH
    • Oral or injectable medicines
    • Oral or oral medicines for BPH
    • Medications for BPH
    • Other medications for erectile dysfunction

    Tell your doctor about all medications, supplements, or herbal products you are currently taking, including prescription and over-the-counter medications, vitamins, and herbal products.